An assassination attempt is made on the life of the president by a teleporting mutant. This act upsets the entire world and entices the president to begin the mutant-human war as predicted by Charles Xavier earlier. In an effort to get to the bottom of the attack and prevent world-wide war, Xavier sends out Storm and Dr. Jean Grey to search for the teleporting mutant and discover the truth behind the assassination attempt.

Dr. Gregory House and his hand-picked team of young medical experts will do whatever it takes to solve the puzzles that other doctors give up on.